Personal

Name: Ippei Kanazawa

Sex: Male

Birth year: 1974

Place of Birth: Osaka Prefecture, Japan

Citizenship: Japanese

Education

1993       Graduated from Shijonawate High School

2001       M.D. Shimane University School of Medicine

2009       Ph.D (Medical Science) Shimane University Graduate School of Medicine

 

Professional Training and Employment

2016-present      Senior Lecturer of Medicine in Division of Internal Medicine 1,

                           Shimane University Faculty of Medicine, Izumo, Shimane, Japan 

2012-2015          Assistant Professor of Medicine in Division of Internal Medicine 1,

                            Shimane University Faculty of Medicine, Izumo, Shimane, Japan 

2009-2012          Postdoctoral fellow in Calcium Research Laboratory, McGill University, Montreal, Quebec, Canada

                            Mentor and research supervisor: Geoffrey N. Hendy, Ph.D.

                           Supported by fellowships from Fonds de la recherché en santé Quebec,

                           Government of Canada, Uehara Memorial Foundation, and Kanae

                           Foundation for the promotion of medical science.

2007-2009          Assistant Professor of Medicine in Division of Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Shimane, Japan

                            Mentor and research supervisor: Toshitsugu Sugimoto, M.D., Ph.D.

2004-2007          Senior Resident in Endocrinology, Metabolism, and Internal medicine, Shimane University Faculty of Medicine, Izumo, Shimane, Japan

                            Clinical Mentors: Yuzuru Kato, M.D., Ph.D. and Toshitsugu Sugimoto, M.D., Ph.D.

2003-2004          Resident in Internal Medicine, Ochi Hospital, Ochi, Shimane, Japan

                            Program Director: Yuzuru Kato, M.D., Ph.D.

Clinical Mentor: Kazunari Sota, M.D.

2001.12-2003      Resident in Endocrinology, Metabolism, and Internal Medicine, Masuda Red Cross Hospital, Masuda, Shimane, Japan

                            Program Director: Yuzuru Kato, M.D., Ph.D.

Clinical Mentor: Motoi Sohmiya, M.D., Ph.D.

2001.4-2001.11   Resident in Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Shimane, Japan

                            Program Director: Yuzuru Kato, M.D., Ph.D.

Clinical Mentor: Toshiaki Mori, M.D., Ph.D.

Title of Dissertation and Ph.D Supervisor

Activation of AMP-kinase and inhibition of Rho-kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expression.

Supervisor: Toshitsugu Sugimoto, M.D., Ph.D., Shimane University Faculty of Medicine

Licensure and Certification

2008       Board certified diabetologist of Japan Diabetes Society 

2008       Board certified endocrinologist of Japan Endocrine Society

2005       Board certified member of Japanese Society of Internal Medicine

2001       Passed the examination of medical doctor of National Board

Societies

2019-     Member, American Diabetes Association

2016-     Councillor, Japan Society for Vascular Failure

2016-     Member, Japan Society for Vascular Failure

2016-     Councillor, Japanese Society for Bone and Mineral Research

2016-     Councillor, Japan Atherosclerosis Society

2016-     Councillor, Japanese Society of Internal Medicine, Branch of Chu-goku region

2014-     Member, European Association for the Study of Diabetes

2013-     Councillor, Japan Endocrine Society

2012-     Member, The Japan Society of Diabetic Complications

2012-     Member, Australian and New Zealand Bone and Mineral Society

2011-     Member, The Society of Craniofacial Genetics and Developmental Biology

2010-     Member, International Bone & Mineral Society

2007-     Member, American Society for Bone and Mineral Research

2007-     Member, Japan Atherosclerosis Society

2007-     Member, Japan Society for the Study of Obesity

2006-     Member, Japanese Society for Bone and Mineral Research

2006-     Member, Japan Osteoporosis Society

2001-     Member, Japan Endocrine Society

2001-     Member, Japan Diabetes Society

2001-     Member, Japanese Society of Internal Medicine

Honors and Awards

2017      Research exhortation award from the Japan Endocrine Society

2016      Young Investigator award from the Japan Society of Diabetic Complications

2016      Research exhortation award from the Japanese Society for Bone and Mineral Research

2012      Research exhortation award from the Japan Osteoporosis Society

2012      ANZBMS 2012 Travel award from the Japanese Society for Bone and Mineral Research

2011      Best presentation award on the 2011 New Therapeutics Targets & Diagnostics in Musculoskeletal Disorders meeting

2011      Travel award on Annual McGill University Endocrine Retreat 2011

2009      Research exhortation award from Ho-unkai (Alumni Association of Shimane University Faculty of Medicine)

2007      Plenary poster on American Society for Bone and Mineral Research 29th Annual Meeting

2007      Research exhortation award from the Japan Osteoporosis Society

2007      Plenary research award from the Japan Endocrine Society

2006      Academic exhortation award from the Japan Osteoporosis Society

2006      Asia travel award from the Japanese Society for Bone and Mineral Research

Scholarship and Support

2014      A Research Grant from National Osteoporosis Foundation

2012      A Research Grant from Uehara Memorial Foundation     

2012      The Naito Foundation Natural Science Scholarship

2012      Support for young staff of Shimane University 2012

2012      9th IDF WPR Congress & 4th AASD Scientific Meeting Travel Support

2012      27th Basic medical science and medical care research fellowship from The Ichiro

             Kanehara Foundation

2011      Student conference support from The Network for Oral and Bone Health Research

2011       Post-Doctoral Research Fellowships from Government of Canada 2011-2012

              Duration from September 2011 to August 2012

              declined due to moving to Japan in March 2012

2011       Postdoctoral training award renewal from Fonds de la recherché en santé Quebec

              Duration; from May 2011 to April 2012

declined due to obtaining Post-Doctoral Research Fellowship from Government of Canada in August 2011

2010       Student conference support from The Network for Oral and Bone Health Research

2010       Abroad research fellowship from Uehara Memorial Foundation

              Duration; from April 2010 to March 2011

2010       Abroad research award from Kanae Foundation for the promotion of medical science

              Duration; from April 2010 to March 2011

2009       Postdoctoral training award from Fonds de la recherché en santé Quebec 

              Duration; from May 2009 to April 2011

Grant Support

    2018-2020 Grant-in-Aid for Scientific Research of the Japanese Government

                    Grant-in-Aid for Scientific Research (C)

                    Title; Roles of AMP kinase, an energy sensor, in bone and glucose metabolism

                    Principal investigator; Kanazawa I 

 

    2016-2019 Grant-in-Aid for Scientific Research of the Japanese Government

                    Grant-in-Aid for Scientific Research (C)

                    Title; The regulatory system of muscle tissue by bone

                    Principal investigator; Sugimoto T

                    Member of this research project; Kanazawa I 

     

    2015-2018 Grant-in-Aid for Scientific Research of the Japanese Government

                    Grant-in-Aid for Scientific Research (C)

                    Title; An in vivo study on the role of AMP kinase in bone formation using osteoblast-specific knockout mice of AMP kinase

                    Principal investigator; Kanazawa I 

 

    2013-2015 Grant-in-Aid for Scientific Research of the Japanese Governmenr

                    Grant-in-Aid for Young Scientists (B)

                    Title; The role of osteocalcin in the interaction among bone, adipose tissue, and muscle

                    Principal investigator; Kanazawa I 

 

    2013-2016 Grant-in-Aid for Scientific Research of the Japanese Government

                    Grant-in-Aid for Scientific Research (C)

                    Title; The regulatory system of bone metabolism by digestive organs

                    Principal investigator; Sugimoto T

                    Member of this research project; Kanazawa I 

     

  2012-2014 Grant-in-Aid for Scientific Research of the Japanese Government

                  Research Activity Start-up

    Title; Can factors regulating energy homeostasis regulate bone metabolism

    and be an important factor for the linkage between glucose and bone

    metabolism? 

    Principal investigator; Kanazawa I 

 

     2008-2010 Grant-in-Aid for Scientific Research of the Japanese Government

    Grant-in-Aid for Scientific Research (C)

    Title; Clarification of etiology of diabetes-related bone disorder

    Principal Investigator; Yamaguchi T

    Member of this research project; Kanazawa I, Yamamoto M

Editorial Board Member

World Journal of Diabetes, 2017-

Datasets Papers in Medicine, 2012-

ISRN Nutrition, 2012-

Journal of Diabetes Research and Clinical Metabolism, 2011-

Internal Medicine - Open Access, 2011-

Chinese Journal of Clinicians, 2011-2014

Journal of Diabetes & Metabolism, 2010-

Ad-hoc Reviewer: the name of journal (the number of times)

Journal of Bone and Mineral Metabolism (28), The Journal of Clinical Endocrinology and Metabolism (15), Endocrine Journal (14), Bone (13), Clinical Endocrinology (10), Journal of Diabetes Investigation (10), Experimental and Clinical Endocrinology & Diabetes (7), Diabetes Research and Clinical Practice (6), Osteoporosis International (6), Clinica Chimica Acta (4), Biomarkers in Medicine (4), Internal Medicine (4), Journal of Atherosclerosis and Thrombosis (4), Acta Diabetologica (3), Cardiovascular Diabetology (3), European Journal of Endocrinology (3), Hormone and Metabolic Research (3), Journal of Diabetes Research & Clinical Metabolism (3), Medical Science Monitor (3), BMJ Open Diabetes Research & Care (2), Cell Metabolism (2), European Journal of Obstetnics & Gynecology and Reproductive Bilogy (2), Expert Review of Endocrinology and Metabolism (2), International Journal of Endocrinology (2), International Journal of Molecular Sciences (2), Journal of Diabetes and Its Complications (2), Journal of Diabetes Research (2), Molecular and Cellular Endocrinology (2), Shimane Journal of Medical Science (2), World Journal of Diabetes (2), Advances in Endocrinology (1), American Journal of Case Reports (1), BBA-General Subjects (1), Calcified Tissue International (1), Canadian Journal of Physiology and Pharmacology (1), Cell Biology International (1), Clinical Interventions in Aging (1), Current Diabetes Reviews (1), Diabetes Management (1), Diabetes/Metabolism Research and Reviews (1), Diabetes, Obesity and Metabolism (1), Diabetologia (1), Diabetology & Metabolic Syndrome (1), Disease Markers (1), Eodocrine (1), Endocrine, Metabolic & Immune Disorders-Drug Target (1), Endocrine Research (1), European Journal of Pediatrics (1), Experimental Gerontology (1), Expert Opinion On Therapeutic Target (1), Future Cardiology (1), Journal of Biomarkers (1), Journal of Bone and Mineral Research (1), Journal of Diabetes (1), Journal of Diabetes & Metabolism (1), Journal of Endocrinological Investigation (1), Journal of Endocrinology (1), Journal of Hormones (1), Journal of Immigrant and Minority Health (1), Journal of Internal Medicine (1), Journal of Nutrition and Metabolism (1), Journal of Osteoporosis (1), Journal of Pediatric Endocrinology and Metabolism (1), Journal of Research in Diabetes (1), Journal of the American College of Nutrition (1), Journal of Translational Medicine (1), Macedonian Journal of Medical Sciences (1), Pathology and Laboratory Medicine International (1), PLOS ONE (1), Renal Failure (1), Therapeutics and Clinical Risk Management (1), Trends in Endocrinology and Metabolism (1), Trends in Molecular Medicine (1), Vascular Health and Risk Management (1), Yonsei Medical Journal (1)

Areas of special interest and accomplishments

Most significant contributions

1) The role of adiponectin in bone metabolism

It has been demonstrated that adiponectin and its receptors are expressed in osteoblasts, suggesting that adiponectin may carry signals from adipose tissue and may have a function in bone tissue as well. In fact, in our clinical study, we found that serum adiponectin level was negatively associated with bone mineral density (BMD) and positively with chemical bone turnover markers as well as with the presence of vertebral fractures (Eur J Endocrinol). We revealed first that adiponectin stimulated the differentiation and mineralization of osteoblastic cells by using siRNA of adiponectin receptor type 1 and activated AMP-kinase (BMC Cell Biol). We published for the first time that activation of AMP-kinase stimulated the differentiation and mineralization of osteoblastic cells by enhancing BMP-2 expression through inhibiting the mevalonate pathway (BMC Cell Biol, Am J Physiol Endocrinol Metab). We also revealed that metformin, an anti-diabetic agent, stimulated the differentiation of osteoblast via BMP-2 expression (Biochem Biophys Res Commun). AMP-kinase activation leaded to inhibit Rho-kinase, resulting in BMP-2 expression and the differentiation of osteoblastic lineage (Am J Physiol Endocrinol Metab, Endocr J). In addition, activation of AMP-kinase and inhibition of Rho-kinase rescues the dexamethasone-induced suppression of the mineralization in osteoblasts via enhancing BMP-2 signal. (Hormone and Metabolic Research). This work is partially supported by Japan Osteoporosis Society. Japanese Society for Bone and Mineral Research gave us an opportunity to present the results in 3rd IOF Asia-Pacific Regional Conference on Osteoporosis and 16th Annual Meeting of the Australian & New Zealand Bone & Mineral Society (Asian travel award). And, this work was selected as a plenary poster in American Society for Bone and Mineral Research 29th Annual Meeting.

 

2) Predictors of bone fragility in type 2 diabetes mellitus

It has been shown that patients with type 2 diabetes mellitus (T2DM) have higher BMD than that in non-diabetic controls, despite an increased risk of osteoporotic fractures. This finding suggests that BMD measurement seems to be less useful in patients with T2DM. It is therefore an urgent task to seek suitable surrogate markers for diabetes-related bone disease that supplement the insensitivity of BMD and assess fracture risk in T2DM. We published for the first time that IGF-I and SDMA in postmenopausal women as well as adiponectin, OC/BAP ratio, combination of HbA1c and BMI, and ADMA in men are associated with the presence of vertebral fracture independent of BMD in cross-sectional analyses (Osteoporos Int (2), Clin Endocrinol, Calcif Tissue Int (2), Eur J Endocrinol). We are going to conduct longitudinal studies to examine these parameters could be predictors of osteoporotic fractures in T2DM. The study reported the association of IGF-I with vertebral fracture was awarded by Japan Osteoporosis Society.

 

3) The association between bone and glucose metabolism

Accumulating evidence indicates that bone metabolism and energy homeostasis are associated with each other. Adipocytokines such as leptin and adiponectin are reported to influence bone metabolism. Several animal studies using genetic mutant mice showed that osteocalcin secreted from osteoblasts stimulated the expression of insulin in pancreas and of adiponectin in adipocytes. We published for the first time that serum osteocalcin and undercarboxylated osteocalcin levels were independently and negatively correlated with plasma glucose level and visceral fat mass as well as serum adiponectin level in patients with T2DM (J Clin Endocrinol Metab, Osteoporos Int). We also found that serum osteocalcin was associated with the parameter of insulin secretion and its sensitivity in T2DM (Bone). In addition, we reported a longitudinal study showing that change in serum osteocalcin was inversely associated with change in glucose level (Diabetes Res Clin Pract). Based on this concept, it is assumed that osteocalcin might be involved in atherosclerotic disease. We revealed for the first time that serum osteocalcin was inversely associated with parameters of atherosclerosis independently of other risk factors (J Clin Endocrin Metab) as well as the deterioration of the parameters (Diabetes Res Clin Pract). Thus, we are going to conduct a large scale longitudinal study to examine the association between osteocalcin and incidence of T2DM and cardiovascular diseases.

 

Areas of interest

  1. The role of adiponectin and its signaling pathway in osteoblast and bone metabolism
  2. The effects of AMP-kinase activation and of Rho-kinase inhibition on osteoblast differentiation and their mechanisms
  3. The association between osteocalcin and glucose metabolism
  4. Predictors of bone fragility in type 2 diabetes mellitus
  5. The association between atherosclerosis and bone metabolism
  6. The role of menin in bone formation and bone metabolism
  7. The effect of calcium sensing receptor on osteoblast differentiation and bone formation

 

Publication

Original articles:

I am first author on thirty-two as well as corresponding author on twenty-one of these papers. A total of IF is 137.806 as of April 2012. Please see Appendix A for complete citation metrics. My unique ISI Researcher ID is F-8609-2010 (see www.researcherid.com) and this can be used to gain access to updated citation metrics (although it takes some time for the newest articles to get into their system). 

 

Please see 研究業績